What Are Fisetin and Quercetin? Antioxidant Powerhouses Explained
- Juvenology Clinic
- Mar 21
- 5 min read
Updated: 2 days ago
Introduction
Ageing is a natural part of life, but that doesn’t mean we have to accept all the changes, especially when it comes to our skin. Those fine lines, wrinkles, and loss of elasticity? You're definitely not alone in noticing them!
As we age, senescent cells build up in our skin, and these cells no longer function properly, causing dullness, sagging, and wrinkles.
But here’s the good news: Fisetin and Quercetin, two powerful natural compounds found in everyday foods like strawberries, apples, and onions, can help clear out these ageing cells.
Key Takeaways
Senescent cells contribute to skin ageing, causing wrinkles, loss of elasticity, and dullness.
Fisetin and Quercetin, powerful antioxidants in foods like strawberries and onions, are senolytics that clear dysfunctional cells from the skin.
These compounds support skin regeneration, promoting a youthful appearance.
Together, Fisetin and Quercetin work synergistically to improve skin texture, smoothness, and radiance by fighting oxidative stress and reducing inflammation.
Incorporating these supplements into your daily routine can improve skin health without harsh chemicals or invasive treatments.
Fisetin and Quercetin also benefit overall health, supporting brain function, cardiovascular health, and reducing the risk of chronic diseases.
Adding these compounds to your biohacking toolkit helps improve both skin and overall well-being.
1. Understanding Senescent Cells in Ageing Skin
When we think about ageing, we often focus on fine lines, wrinkles, and sagging skin, but what’s happening beneath the surface is just as important. Senescent cells are a big part of the picture. These are cells that have stopped dividing and functioning properly, but instead of naturally dying off, they linger and release harmful substances that create oxidative stress and inflammation. This contributes to wrinkles, age spots, and a dull complexion, making your skin look tired and saggy.
Fisetin
Antioxidant Activity: High, neutralizes free radicals
Senolytic Properties: Strong, clears senescent cells
Skin Benefits: Improves skin texture, elasticity, and reduces fine lines
Main Mechanism of Action: Clears senescent cells, fights oxidative stress
Additional Benefits: May improve memory and cognitive function
Quercetin
Antioxidant Activity: High, protects against oxidative damage
Senolytic Properties: Strong, reduces inflammation and senescent cells
Skin Benefits: Reduces puffiness, calms inflammation, and supports collagen production
Main Mechanism of Action: Reduces inflammation and supports cellular turnover
Additional Benefits: May support heart health and reduce allergic responses
But understanding how senescent cells work and their impact on skin health is just the first step. In the next section, we’ll look more closely at how Fisetin can help address these ageing cells in a way that’s both natural and effective.
2. The Science Behind Fisetin
Let’s talk about Fisetin, a skin-loving compound you might already be enjoying in foods like strawberries, apples, and grapes! This antioxidant superhero helps protect your skin from oxidative stress, which is one of the main causes of wrinkles, sagging, and dullness.
But Fisetin does even more, it’s also a senolytic, meaning it helps clear out senescent cells, those "zombie" cells that speed up ageing.
By reducing inflammation and promoting skin regeneration, Fisetin helps your skin refresh and renew, leaving you with a smoother, healthier complexion. It’s a gentle, natural way to restore that youthful glow!
3. The Role of Quercetin in Cellular Health
Enter Quercetin, the bold and confident partner to Fisetin! Found in foods like blueberries, apples, and onions, Quercetin works alongside Fisetin to combat skin ageing in perfect harmony. Like Fisetin, Quercetin is a potent antioxidant that tackles oxidative stress, but its
properties really make it shine. It helps calm redness, puffiness, and irritation, common signs of ageing.
Together, Quercetin and Fisetin form a dynamic duo, working synergistically to address both visible signs of ageing and the underlying cellular damage. By adding Quercetin to your routine, you’re helping maintain smooth, supple skin for a vibrant, youthful appearance.
4. How Fisetin and Quercetin Work
Fisetin & Quercetin as a Duo: Together, they enhance each other's effects for powerful skin rejuvenation.
Senolytic Superpowers: Their combined properties clear ageing cells, improving skin texture and elasticity.
Fisetin’s Role: Fights oxidative stress, clears senescent cells, and supports skin regeneration.
Quercetin’s Role: Soothes inflammation, reduces redness, and promotes healthy skin turnover.
Synergy in Action: Fisetin clears aged cells, Quercetin calms, nurturing smoother skin.
Skin Elasticity & Anti-Ageing: Reduces fine lines and wrinkles, boosting skin elasticity for a youthful glow.
Holistic Solution: A natural, effective way to achieve smoother, more radiant skin.
Key Benefits of Fisetin and Quercetin for Skin Health
Fisetin Benefits:
Reduces fine lines and wrinkles by clearing senescent cells and promoting cell turnover.
Boosts skin elasticity by encouraging collagen production.
Mild anti-inflammatory effects, reducing redness and puffiness.
Acts as an antioxidant, protecting skin from free radical damage.
Supports hydration and promotes a more vibrant complexion.
Quercetin Benefits:
Reduces fine lines and wrinkles by addressing oxidative stress and inflammation.
Improves skin elasticity through healthy cell turnover.
Strong anti-inflammatory properties, reducing puffiness and redness.
Antioxidant protection against free radical damage for a youthful glow.
Helps clear senescent cells, promoting healthier, more vibrant skin.
Supports hydration by reducing inflammation and oxidative stress.
Combined Effect: Fisetin and Quercetin work together to clear senescent cells, reduce inflammation, provide antioxidant protection, and promote smoother, more radiant skin.
5. Incorporating Fisetin and Quercetin into Your Routine
To make the most of Fisetin and Quercetin for your skin, here’s a simple way to incorporate them into your daily routine!
Choose high-quality supplements: Opt for well-reviewed supplements that combine Fisetin and Quercetin for the best results.
Start slow: Begin with a low dose and gradually increase, consulting a healthcare professional if needed.
Stay consistent: Take your supplements daily to see improvements in skin texture and radiance over time.
Pair with a healthy lifestyle: Support your skin with a balanced diet, hydration, good sleep, and regular exercise.
Don’t forget skincare: Enhance your routine with products like vitamin C or retinol.
Dosage Guidelines for Fisetin and Quercetin Supplements for Skin Health
Fisetin
Dose: 100-500 mg/day
Form: Capsules, Tablets, Powder
Results: 4-8 weeks
Quercetin
Dose: 500-1000 mg/day
Form: Capsules, Tablets
Results: 2-4 weeks
By incorporating Fisetin and Quercetin into your daily routine, along with a holistic approach to skincare and healthy living, you’ll be on your way to clearer, more youthful skin. It’s all about being proactive and consistent with these simple, natural tools for anti-ageing.
Final Thoughts
As we age, senescent cells contribute to wrinkles, sagging, and a dull complexion, but Fisetin and Quercetin, two powerful flavonoid antioxidants, can help clear these cells and fight oxidative stress and inflammation. When combined, they work together to promote smoother, youthful-looking skin, improving texture, reducing fine lines, and restoring a healthy glow. By consistently incorporating high-quality supplements, along with a balanced lifestyle, you’ll see noticeable results.
About the Author
Marina, Longevity Specialist
Hi there! I’m Marina, and I specialize in longevity and healthy ageing here at Juvenology Clinic. While our clinic is based in Kent and London, I’m available to conduct tests and offer support worldwide. If you're interested in exploring how to age healthily and feel your best, don’t hesitate to reach out, I’d love to help!
I’ve had the privilege of training at the Academy for Healthy Longevity, which is part of the renowned Yong Loo Lin School of Medicine at the National University of Singapore. The Academy is led by world-class experts and supported by a distinguished advisory board, pushing the boundaries of research and education in Precision Geromedicine. It’s been such an exciting journey to learn from the best and stay at the forefront of the latest in healthy ageing!
